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Moving Away From Animal Testing: The Case Against The Biological Reactivity Test - BLOG

HISTORY OF THE TEST The test was first introduced at during the early part of the twentieth century, at a time when pharmaceutical products were less controlled than they are now. The test was developed in 1906 due to the presence of phenol in some medicinal products (1, 2). This animal test was developed to ensure the safe and consistent production of serum products, for example, to titrate the preservative level of diphtheria antiserum (3). It was later expanded to a general ‘safety’ test to detect extraneous contaminants (other than, for example, bacterial endotoxins) in biological...

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